The declining levels of progesterone and estrogen that occur during perimenopause/menopause cause a myriad
of symptoms that drastically change a woman's quality of life—generally not for the better. This can result in
feelings of sadness that may evolve into depression. Progesterone and estrogen also influence neurotransmitters
that regulate mood. When levels of these hormones drop, menopausal women may also find it difficult to restore
happiness and calm after bouts of sadness, anxiety, and irritability, which can also contribute to depression.